Is a neurotransmitter that occurs in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors—D1, D2, D3, D4, and D5—and their variants.
Role in movement
Role in pleasure and motivation
Controls the flow of information from other areas of the brain
D1 receptors regulate neuronal growth and development, mediate some behavioral responses,
D2 inhibits adenylyl cyclase activity
D3 receptor plays a role in cognitive and emotional functions
D4 receptor is considered to be D2-like in which the activated receptor inhibits the enzyme adenylate cyclase, thereby reducing the intracellular concentration of the second messenger cyclic AMP
D5 receptor Expression in nucleus of thalamus ;suggesting
that role in pain stimuli
Categories:
Drug Information